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Improving the Design of Ion Track-Based Biosensors

  • D. Fink
  • A. Kiv
  • L. Alfonta
  • H. García-Arrellano
  • H. G. Muñoz
  • J. Vacik
  • V. Hnatowicz
  • Yu. Shunin
  • Yu. Bondaruk
  • A. Mansharipova
  • R. Mukhamediyev
Conference paper
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)

Abstract

In the last decade we had developed new types of biosensors, by cladding the inner walls of transparent etched swift heavy ion tracks in thin polymer foils with enzymes. The enzymatic reaction products of appropriate analytes penetrating into narrow tracks are enriched in the track’s confinement, and they change the electrical track properties if their charge states differ from those of the analytes. It was yet unknown how to design these sensors so that their best efficiency and highest possible sensitivity is achieved. This requires the accurate knowledge of the optimum track radius and the degree of product enrichment within the tracks. These questions were answered by appropriate experiments described here. The above studies restricted to transparent tracks only. After it became evident that also thin membranes can be formed within such tracks – thus separating transparent tracks into two adjacent semi-transparent segments each – we were curious in how far such structures might also become useful as sensors. In fact, two promising approaches emerged, one that uses these structures as polarization-induced capacitive biosensors, and another one that considers the semitransparent track segments as neighboring “electrostatic bottles” which can be discharged by pulse-wise product emission. Preliminary results indicate that the latter sensor type is superior in its performance to all other ones.

Keywords

Biosensors Nanopores Heavy ion tracks 

Notes

Acknowledgements

D.F. is grateful to the Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, for the guest professorship in the frame of the Cathedra “Alonso Fernandez”. We are especially obliged to Prof. S.A. Cruz and Mr. N. Camarillo from UAM-Iztapalapa for their continuous help and discussions and for providing us with adequate working facilities. The project was supported by the Grant Agency of the Czech Republic (P108-12G-108) and the Nuclear Physics Institute, Řež near Prague. We are further obliged to Dr. P. Apel from JNRI Dubna, Russia for providing us with the ion-irradiated foils. L.A. acknowledges the support of the Edmond J. Safra Center for the Design and Engineering of Functional Biopolymers at Ben-Gurion University.

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • D. Fink
    • 1
    • 2
  • A. Kiv
    • 3
    • 4
  • L. Alfonta
    • 5
  • H. García-Arrellano
    • 6
  • H. G. Muñoz
    • 1
  • J. Vacik
    • 2
  • V. Hnatowicz
    • 2
  • Yu. Shunin
    • 7
    • 8
  • Yu. Bondaruk
    • 4
  • A. Mansharipova
    • 9
  • R. Mukhamediyev
    • 9
  1. 1.Departamento de FisicaUniversidad Autónoma Metropolitana-IztapalapaMéxicoMéxico
  2. 2.Nuclear Physics InstituteŘežCzech Republic
  3. 3.Department of Materials EngineeringBen-Gurion University of the NegevBeer-ShevaIsrael
  4. 4.South-Ukrainian National Pedagogical University after K.D. UshinskijOdessaUkraine
  5. 5.Avram and Stella Goldstein-Goren Department of Biotechnology EngineeringBen-Gurion University of the NegevBeer-ShevaIsrael
  6. 6.Departamento de Ciencias Ambientales, Division de Ciencias Biológicas y de la SaludUniversidad Autónoma Metropolitana-LermaLerma de Villada, Municipio de LermaMéxico
  7. 7.Institute of Solid State Physics of the University of LatviaRigaLatvia
  8. 8.Ventspils University CollegeVentspilsLatvia
  9. 9.Kazakh-Russian Medical UniversityAlmatyKazakhstan

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