The Application of Reverse Engineering Technology in Orthopaedics

  • Qin Lian
  • Yaxiong Liu

Reverse Engineering in the Design of Customized Prosthesis

For patients with bone defects, the traditional repair methods are bone graft and implant general prosthesis. Nevertheless, the bone graft is poorly moulded, cannot correct the deformity and is prone to complications. Without bone shape, general prosthesis needs processing adjustment according to the demands of the patient during the operation, which is dependent on the surgeon’s experience, and the adjustment mostly doesn’t match with the autologous bone of the patient, which not only affects the appearance but also causes the decreases of bearing capacity, inaccurate positioning and unstable connection. All these problems easily cause the failure of the bone defect repairing and serious impact on physical and psychological rehabilitation of patients after operation. A fundamental way to solve the problem is to design a tailored customized prosthesis for patient. With the development of medical image processing technology, it...


  1. 1.
    Pallua N, Suscheck CV, Reichert JC, Hutmacher DW. Bone tissue engineering. Tissue engineering. Berlin Heidelberg: Springer; 2011. p. 431–56.Google Scholar
  2. 2.
    O’Keefe RJ, Mao J. Bone tissue engineering and regeneration: from discovery to the clinic—an overview. Tissue Eng B Rev. 2011;17:389–92.CrossRefGoogle Scholar
  3. 3.
    Li X, Bian W, Li D, Lian Q, Jin Z. Fabrication of porous beta-tricalcium phosphate with microchannel and customized geometry based on gel-casting and rapid prototyping. Proc Inst Mech Eng H. 2011;225:315–23.PubMedGoogle Scholar
  4. 4.
    Xu S, Li D, Lu B, Lian Q. Study on two-phase flow of cell and cell suspension in artificial bone microtubules. China Mech Eng. 2006;17:67–70.Google Scholar
  5. 5.
    Xu S, Li D, Lu B, Tang Y, Wang C, Wang Z. Fabrication of a calcium phosphate scaffold with a three-dimensional channel network and its application to perfusion culture of stem cells. Rapid Prototyp J. 2007;13:99–106.CrossRefGoogle Scholar
  6. 6.
    Li X, Li D, Lu B, Tang Y, Wang L, Wang Z. Design and fabrication of CAP scaffolds by indirect solid free form fabrication. Rapid Prototyp J. 2005;11:312–8.CrossRefGoogle Scholar
  7. 7.
    Hollister SJ. Porous scaffold design for tissue engineering. Nat Mater. 2005;4:518–24.CrossRefGoogle Scholar
  8. 8.
    He J, Li D, Lu B, Wang Z, Zhang T. Custom fabrication of a composite hemi-knee joint based on rapid prototyping. Rapid Prototyp J. 2006;12:198–205.CrossRefGoogle Scholar
  9. 9.
    Roelofs AJ, Rocke JPJ, De Bari C. Cell-based approaches to joint surface repair: a research perspective. Osteoarthr Cartil. 2013;21:892–900.CrossRefGoogle Scholar
  10. 10.
    Zaslav K, McAdams T, Scopp J, Theosadakis J, Mahajan V, Gobbi A. New frontiers for cartilage repair and protection. Cartilage. 2012;3:77S–86S.CrossRefGoogle Scholar
  11. 11.
    Yang PJ, Temenoff JS. Engineering orthopedic tissue interfaces. Tissue Eng Part B Rev. 2009;15:127–41.CrossRefGoogle Scholar
  12. 12.
    Bian W, Li D, Lian Q, Zhang W, Zhu L, Li X, et al. Design and fabrication of a novel porous implant with pre-set channels based on ceramic stereolithography for vascular implantation. Biofabrication. 2011;3:034103.CrossRefGoogle Scholar
  13. 13.
    Hoemann CD, Lafantaisie-Favreau C-H, Lascau-Coman V, Chen G, Guzman-Morales J. The cartilage-bone interface. J Knee Surg. 2012;25:85–97.CrossRefGoogle Scholar
  14. 14.
    Liu Y, Lian Q, He J, Zhao J, Jin Z, Li D. Study on the microstructure of human articular cartilage/bone Interface. J Bionic Eng. 2011;8:251–62.CrossRefGoogle Scholar
  15. 15.
    Bian W, Lian Q, Li D, Zhang W, Jin Z Hierarchical Structure of Articular Bone-Cartilage Interface and Its Potential Application for Osteochondral Tissue Engineering. Proceedings of the 9th International Conference on Frontiers of Design and Manufacturing July 17 ~ 19, 2010, Changsha, China.Google Scholar
  16. 16.
    Bian W, Li D, Lian Q, Li X, Zhang W, Wang K, et al. Fabrication of a bio-inspired beta-Tricalcium phosphate/collagen scaffold based on ceramic stereolithography and gel casting for osteochondral tissue engineering. Rapid Prototyp J. 2012;18:68–80.CrossRefGoogle Scholar
  17. 17.
    Zhang W, Lian Q, Bian W, Wang K, Jin Z, Li D. Critical-size Defect Repair Using Osteochondral Composite by Additive Manufacturing. Proceedings of the 11th International Conference on Frontiers of Design and Manufacturing May 23 ~ 25, 2014, Nanjing, China.Google Scholar
  18. 18.
    Zhang W, Lian Q, Li D, Wang K, Hao D, Bian W, et al. Cartilage repair and subchondral bone migration using 3D printing osteochondral composites: a one-year-period study in rabbit trochlea. Biomed Res Int. 2014;2014:746138.PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Nature B.V. and People's Medical Publishing House 2018

Authors and Affiliations

  • Qin Lian
    • 1
  • Yaxiong Liu
    • 1
  1. 1.State Key Laboratory for Manufacturing System EngineeringSchool of Mechanical Engineering, Xi’an Jiaotong UniversityXi’anChina

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