Neurourology pp 231-259 | Cite as

Drug Treatment

  • Karl-Erik AnderssonEmail author
  • Helmut Madersbacher
  • Waleed Altaweel
  • Pawan Vasudeva
  • Yasuhiko Igawa


Neurogenic lower urinary tract dysfunction (NLUTD) is a heterogeneous combination of symptoms and urodynamic findings that are the result of neurological injury to the bladder (Fig. 27.1) [1–4]. The patterns of bladder storage and voiding disturbances depend on the lesion of neurologic lesion (Fig. 27.2). Patients often have incontinence, urgency, frequency and/or impaired bladder emptying. Urodynamically, there is often poor bladder wall compliance, neurogenic detrusor overactivity (NDO) and/or detrusor sphincter dyssynergia (DSD) which may result in morphological changes in the bladder wall, such as trabeculations and diverticulae. NLUTD can be found in 85–90% of patients with spinal cord injury (SCI), with urinary incontinence occurring in more than 50% NLUTD also occurs in 50–80% of patients with multiple sclerosis (MS), in 27–64% of patients with Parkinson’s disease, and in over 95% of patients with spina bifida [3]. It also occurs frequently with many other neurological conditions such as after stroke, transverse myelitis, and autonomic disorders [1–4].


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Karl-Erik Andersson
    • 5
    Email author
  • Helmut Madersbacher
    • 4
  • Waleed Altaweel
    • 3
  • Pawan Vasudeva
    • 2
  • Yasuhiko Igawa
    • 1
  1. 1.Department of Continence MedicineThe University of Tokyo Graduate School of MedicineTokyoJapan
  2. 2.VM Medical College, Safdarjang HospitalDelhiIndia
  3. 3.Department of UrologyKing Faisal Specialist Hospital and Research CenterRiyadhSaudi Arabia
  4. 4.Department of UrologyUniversity HospitalInnsbruckAustria
  5. 5.Department of Clinical MedicineUniversity of AarhusAarhusDenmark

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