Maternal-fetal Incompatibility and Heterozygote Advantage in Mouse Transferrins
A mouse colony segregating for serum transferrins was established by crossing two inbred strains with different transferrin alleles, and randomly breeding subsequent generations. The progeny from the F3, F4, F5 and F6 generations were examined for transferrin type. There was significant deviation (P < 0.025) from the expected 1:1 ratio in the compatible matings a♂ × ab♀ and b♂ × ab♀, with 46.9% homozygotes and 53.1% heterozygotes. There was no segregation disturbance in the incompatible matings, equal numbers of homozygotes and heterozygotes being produced.
The segregation from ab × ab matings did not differ from expectation, although there were significantly more Trfb than Trfa genes in the progeny (P < 0.05).
It is suggested that the advantage of the heterozygote in compatible matings may be one component of the balancing mechanism for this polymorphism.
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