Tolerance Induction to H-1 Antigenic Differences in the Rat

  • V. Křen
  • O. Štark


Long-term skin graft tolerance by spleen cells was induced in H-1 compatible strain combinations only indicating the major importance of RtH-1 among rat histocompatibility systems. Partial or complete suppression of antibody formation was the only tolerance manifestation during donor skin graft rejection in all H-1 incompatible strain combinations tested. Moreover, 19 S antibody preponderance was revealed in partly tolerant animals. Thus the dissociation of the cellular and antibody mechanisms of immune response and of two immunoglobulin types was demonstrated on an allogeneic partial tolerance system.


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  1. Asherson, G. L., 1967. Antigen-mediated depression of delayed hypersensitivity, Brit. Med. Bull, 23, 24–29.PubMedGoogle Scholar
  2. Billingham, R. E. and Silvers, W. K., 1959. The induction of tolerance of skin homografts in rats with pooled cells from multiple donors, J. Immunol, 83, 667–679.PubMedGoogle Scholar
  3. Billingham, R. E., Defendi, V., Silvers, W. K. and Steinmuller, D., 1962. Quantitative studies on the induction of tolerance of skin homografts and on runt disease in neonatal rats, J. Nat. Cancer Inst., 28, 365–435.PubMedGoogle Scholar
  4. Brdička, R., Křen, V., Frenzl B. and Štark, O., 1962. Interlineal relationships in rats, Fol. biol. (Praha), 8, 352–359.Google Scholar
  5. Egdahl, R. H., Roller, F. R., Swanson, R. L. and Varco, R. L., 1958. Acquired tolerance to homografts and heterografts in the rat, Ann. N.Y. Acad. Sci., 73, 842–847.PubMedCrossRefGoogle Scholar
  6. Grozdanovič, J., 1959. Long-term passage of skin grafts in immunologically tolerant rats, Fol. biol. (Praha), 5, 108–112.Google Scholar
  7. Křen, V., Braun, A., Štark, O., Kraus, R., Frenzl, B. and Brdička, R., 1962. The runting syndrome in rats and its inhibition by homologous sera, Fol. biol. (Praha), 8, 341–351.Google Scholar
  8. Křen, V., Brdička, R. and Štark, O., 1968. Erythrocyte and transplantation antigens in inbred strains of rats. VIII. The dynamics of 19S and 7S LEW anti-H-1 haemagglutinin production, Fol. biol. (Praha). (In press).Google Scholar
  9. Štark, O., Křen, V., Frenzl, B. and Brdička, R., 1968. The main histocompatibility system of the rat. In: Advance in transplantation, Copenhagen, p. 331–339.Google Scholar
  10. Woodruff, M. F. A. and Simpson, L. O., 1955. Induction of tolerance to skin homografts in rats by injection of cells from the prospective donor soon after birth, Brit. J. Exp. Path., 36, 494–499.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1970

Authors and Affiliations

  • V. Křen
    • 1
  • O. Štark
    • 1
  1. 1.Department of Biology, Medical FacultyCharles UniversityPragueCzechoslovakia

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