Tolerance Induction to H-1 Antigenic Differences in the Rat
Long-term skin graft tolerance by spleen cells was induced in H-1 compatible strain combinations only indicating the major importance of RtH-1 among rat histocompatibility systems. Partial or complete suppression of antibody formation was the only tolerance manifestation during donor skin graft rejection in all H-1 incompatible strain combinations tested. Moreover, 19 S antibody preponderance was revealed in partly tolerant animals. Thus the dissociation of the cellular and antibody mechanisms of immune response and of two immunoglobulin types was demonstrated on an allogeneic partial tolerance system.
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