Advertisement

Further Analysis of the Histocompatibility-1 System of the Rat

  • O. Štark
  • V. Křen
  • B. Frenzl
Chapter

Summary

Antigens determined by the RtH-1 system were studied by means of allogeneic transplantation and by serological methods in 21 inbred strains of rats. Nine different alleles of this system were identified and their structure studied. Each allele determines a typical combination of some individual antigens whose total number has now reached 21. Eight antigens only are specific for different alleles, while the others are shared in common by complex products of two or more alleles. From the point of view of structure the RtH-1 system is analogous to other complex immunogenetic systems analysed in different species of animals.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Billingham, R. E., Hodge, B. A. and Silvers, W. K., 1962. An estimate of the number of histocompatibility loci in the rat, Proc. Nat. Acad. Sci., 48, 138–147.PubMedCrossRefGoogle Scholar
  2. Elkins, W. L. and Palm J., 1966. Identification of a strong histocompatibility locus in the rat by normal spleen-cell transfer, Ann. N. Y. Acad. Sci., 129, 573–580CrossRefGoogle Scholar
  3. Heslop B. F., 1968a. The production of haemagglutinins after skin allografts in the rat, Proc. Univ. Otago Med. Sch., 46, 6–7.Google Scholar
  4. Heslop, B. F., 1968b. Histocompatibility antigens in the rat, the AS2 strain in relation to the AS, BS and HS strains, Aust. J. Exp. Biol. Med. Sci. (In press).Google Scholar
  5. Iványi, P., 1966. Serological production of congenic lines in rats. In: Polymorphismes biochimiques des animaux, Paris, p. 507–510.Google Scholar
  6. Michie, D. and Anderson, N. F., 1966. A strong selective effect associated with a histocompatibility gene in the rat, Ann. N.Y. Acad. Sci., 129, 88–93.CrossRefGoogle Scholar
  7. Ramseder, H. and Palm J., 1967. Further studies of histocompatibility loci in rats, Transplantation, 5, 721–729.CrossRefGoogle Scholar
  8. Štark, O., Frenzl, B. and Křen, V., 1968b. Erythrocyte and transplantation antigens in inbred strains of rats, VII. H-1 alleles of the LEP, CAP, BN, BD V, BD VII and BD X strains, Fol. biol. (Praha), 14, 169–175.Google Scholar
  9. Štark, O. and Křen, V., 1967a. Erythrocyte and transplantation antigens in inbred strains of rats. II. Antigens of the AVN strain, Fol. biol. (Praha), 13, 93–99.Google Scholar
  10. Štark, O. and Křen, V., 1967b. Erythrocyte and transplantation antigens in inbred strains of rats. III. Antigens of the BP strain, Fol. biol. (Praha), 13, 299–305.Google Scholar
  11. Štark, O., Křen, V. and Frenzl, B., 1966. Histocompatibility locus in the rat. In: Polymorphismes biochimiques des animaux, Paris, p. 501–506.Google Scholar
  12. Štark, O., Křen, V. and Frenzl, B., 1967. Erythrocyte and transplantation antigens in inbred strains of rats. I. Serological analysis of strain-specific antigens, Fol. biol. (Praha), 13, 85–92.Google Scholar
  13. Štark, O., Křen, V., Frenzl, B. and Brilička, R., 1968a. The main histocompatibility system of the rat. In: Advance in transplantation, Copenhagen, p. 331–339.Google Scholar
  14. Štark, O., Křen, V., Frenzl B. and Křenová, D., 1968c. Histocompatibility-1 alleles in inbred rats of the BD II, WR, AGA, CDF, AS, BS, HS and DA strains, Fol. biol. (Praha). (In press).Google Scholar
  15. Zeiss, J. M., 1967. Antigenic interrelationships and number of independently segregating histocompatibility loci in three isohistogenic strains of rats, Transplantation, 5, 1393–1399.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1970

Authors and Affiliations

  • O. Štark
    • 1
  • V. Křen
    • 1
  • B. Frenzl
    • 1
  1. 1.Department of Biology, Medical FacultyCharles UniversityPragueCzechoslovakia

Personalised recommendations