Preliminary Studies on Histocompatibility Antigens in Wild Mice (Mus musculus)

  • P. Iványi
  • P. Démant


The number of histocompatibility loci (H loci) at which two inbred mouse strains differ was estimated at 13–30, representing only a small proportion of the total number of more than 430 histocompatibility sites in the mouse (for references see Bailey, 1967). The alleles at the H loci in wild mouse populations can be subject to selective forces either directly or as a result of their linkage with other selectively non neutral loci, probably in supergene complexes. The concept of H-2-T region as a functional unit proposed by Snell (1968) is one of the possible examples of this situation.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bailey, D. W., 1967.* Advances in Transplantation, Munksgaard, Copenhagen, 317–324.Google Scholar
  2. Barnes, A. D. and Krohn, P. L., 1957. The estimation of the number of histocompatibility genes controlling the successful transplantation of normal skin in mice, Proc. Roy. Soc. B., 146, 505–526.CrossRefGoogle Scholar
  3. Billingham, R. E., Hodge, B. A. and Silvers, W. K., 1962. An estimate of the number of histocompatibility loci in the rat, Proc. Nat. Acad. Sci., 48, 138–147.PubMedCrossRefGoogle Scholar
  4. Palm, J., Silvers, W. K. and Billingham, R. E., 1967. The problem of histocompatibility in wild hamsters, J. Heredity, 58, 40–44.Google Scholar
  5. Petras, M. L., 1967a. Studies of natural populations of mus. I. Biochemical polymorphisms and their bearing on breeding structure, Evolution, 21, 259–274.CrossRefGoogle Scholar
  6. Petras, M. L., 1967b. Studies of natural populations of mus. II. Polymorphism at the T locus, Evolution, 21, 466–478.CrossRefGoogle Scholar
  7. Petras, M. L., 1967c. Studies of natural populations of mus. III. Coat color polymorphisms, Can. J. Genet. Cytol, 9, 287–296.PubMedGoogle Scholar
  8. Snell, G. D., 1968. The H-2 locus of the mouse: Observations and speculations concerning its comparative genetics and its polymorphism, Fol. biol. (Prague), (In press).Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1970

Authors and Affiliations

  • P. Iványi
    • 1
  • P. Démant
    • 1
  1. 1.Institute of Experimental Biology and GeneticsCzechoslovak Academy of SciencesPragueCzechoslovakia

Personalised recommendations