Allotypes (Serum Antigens) in Farm Animals
This paper presents our attempts to detect allotypes (serum antigens) in cattle, pigs, mink and sheep. It proved possible to demonstrate that isoimmunization can result in production of antibodies. Thus serum proteins of the species studied are sufficiently different in structure to induce serum protein isoimmunization. At least eleven antigens were discovered in cattle, representing variety of proteins: three macroglobulins, two high density lipoproteins, one albumin, one intra-erythrocyte non-hemoglobin protein. In mink five allotypes were found which represent α-, β- and γ-globulins. Five isoprecipitins were produced in sheep. A large number of allotypes were detected in pigs by using isoimmunosera. Within this group the most interesting are two low density lipoprotein allotypes (LDLpp-1 and LDLpp-2) which are determined by allelic genes.
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