Advertisement

Genetic Aspects of the Immune Response

  • R. D. Owen
Chapter

Abstract

The immune response probably evolved primarily for the advantages it confers on the organism in recovery from infectious disease, and specific protection against reinfection by the same pathogen. The response is characterized by recognition of substances foreign to the organism, elaboration of antibodies with combining sites complementary to parts of the foreign substances that induced antibody formation, and a specific “memory”, such that later exposure to the same or a sufficiently similar foreign substance provokes a more rapid and intense antibody response than did the first exposure. Because the immune response system has evolved by selection, we can assume that its elaboration has depended on genetic variations occurring in the past. In its present form the system is highly complex, involving numerous processes of programmed cellular function, differentiation and interaction. Thus the phylogeny, the ontogeny, and the physiology of the immune response all indicate a high order of genetic dependency.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. A Discussion on the Chemistry and Biology of Immunoglobulins. Organized by Porter, R. R., 1966. Proc. Roy. Soc, B166, 113–243, 11 papers and discussions.Google Scholar
  2. Adler, F. L., Fishman, M. and Dray, S., 1966. Antibody formation initiated in vitro. III. Antibody formation and allotypic specificity directed by RNA from peritoneal exudate cells, J. Immunol., 97, 554–558.PubMedGoogle Scholar
  3. Cohn, M., 1967. The molecular biology of expectation. Rutgers Symposium on Nucleic Acids in Immunology. (In press).Google Scholar
  4. Cold Spring Harbor Symposia on Quantitative Biology, 1967. XXXII, Antibodies. Published by the Cold Spring Harbor Laboratory of Quantitative Biology, Cold Spring Harbor, Long Island, New York, 68 papers, pp. 619Google Scholar
  5. Fleischman, J. B., 1966. Immunoglobulins, Annual Review of Biochemistry, 35, 835–872.PubMedCrossRefGoogle Scholar
  6. Genetics of the Immune Response. Report of a World Health Organization Scientific Group on the Genetics of the Immune Response, E. S. Lennox, Chairman. To be published by World Health Organization.Google Scholar
  7. Gill, T. J. III and Gershoff, S. N., 1968. Genetic control of the antibody response in the rat to structurally different synthetic polypeptide antigens, J. Immunol. (In press).Google Scholar
  8. Greenwalt, T. J. (ed.), 1967. Advances in immunogenetics, J. B. Lippincott, Philadelphia, 7 papers, including 3 on immunoglobulins.Google Scholar
  9. Hollaender, A. (ed.), 1966. Symposium on differentiation and growth of hemoglobin and immunoglobulin synthesizing cells, J. of Cellular Physiol., Suppl. 1, 67, pp. 215.Google Scholar
  10. Howell, J. W., Hood, L. and Sanders, B. G., 1967. Comparative analysis of the IgG heavy chain carbohydrate peptide, J. Mol. Biol., 30, 555–558.PubMedGoogle Scholar
  11. Kabat, E. A., 1968. Structural concepts in immunology and immunochemistry, Holt, Rinehart and Winston, Inc., New York. A concise, up-to-date teaching textbook, pp. 310.Google Scholar
  12. Kbllander, J. (ed.), 1967. Gamma globulins: structure and control of biosynthesis, Proceedings of 3rd Nobel Symposium, Interscience Publishers, John Wiley & Sons, Inc., New York, 48 papers and discussions, pp. 643.Google Scholar
  13. Lamelin, J.-P., Paul, W. E. and Benacerraf, B., 1968. The immune response of random-bred Hartley strain guinea pigs to 2, 4-dinitrophenyl conjugates of a copolymer of L-glutamic acid and L-lysine, J. Immunol., 100, 1058–1061.PubMedGoogle Scholar
  14. Lennox, E. S. and Cohn, M., 1967. Immunoglobulins, Annual Review of Biochemistry, 36, 365–406.PubMedCrossRefGoogle Scholar
  15. Levey, R. H. and Medawar, P. B., 1966. Nature and mode of action of antilymphocytic antiserum, Proc. Nat. Acad. Sci. (U.S.A.), 56, 1130–1137.CrossRefGoogle Scholar
  16. Locke, M. (ed.), 1967. Control mechanisms in developmental processes, 26th Symposium of the Society for Developmental Biology, Academic Press, New York. Note especially the reviews by I. M. London et al., on erythroid cells and hemoglobin; and R. Auerbach, on development of immunocompetent cells.Google Scholar
  17. Maurer, P. and Pinchuck, P., 1968. Immune response of strain 13 guinea pigs to lysine-containing polymers of amino acids, J. Immunol., 100, 1141–1142.PubMedGoogle Scholar
  18. McDevttt, M. D. and Tyan, M. L., 1968. Genetic control of the antibody response by spleen cells and linkage to the major histocompatibility (H-2) locus, J. Exp. Med. (July).Google Scholar
  19. Rich, A. and Davidson, N. (eds.), 1968. Structural chemistry and molecular biology: a volume dedicated to Linus Pauling by his students, colleagues, and friends, W. H. Freeman & Co., San Francisco.Google Scholar
  20. Schroeder, W. A., Huisman, T. H. J., Shelton, J. R., Shelton, J. B., Kleihauer, E. F., Dozy, A. M. and Robberson, B., 1968. Evidence for multiple structural genes for the y chain of human fetal hemoglobin, Proc. Nat. Acad. Sci. (U.S.A.) (In press).Google Scholar
  21. Sell, S., 1968. Zygosity of lymphocyte donor and maximum percent blast transformation induced by antiallotype sera, Federation Proceedings, 27, 277.Google Scholar
  22. Singer, S. J. and Thorpe, N. O., 1968. On the location and structure of the active sites of antibody molecules. Proc. Nat. Acad. Sci. (U.S.A.) (In press).Google Scholar
  23. Smith, R. T., Miescher, P. A. and Good, R. A. (eds.), 1966. Phylogeny of immunity, University of Florida Press, Gainesville.Google Scholar
  24. Smith, R. T., Good, R.A. and Miescher, P. A. (eds.), 1967. Ontogeny of immunity, University of Florida Press, Gainesville.Google Scholar
  25. Wolstenholme, G. E. W. and O’Connor, M. (eds.), 1967. Antilymphocytic serum, Ciba Foundation Study Group No. 29, Little, Brown & Co., Boston. 6 discussion sections, pp. 165.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1970

Authors and Affiliations

  • R. D. Owen
    • 1
  1. 1.California Institute of TechnologyPasadenaUSA

Personalised recommendations