Drug immunoconjugates

  • Malek Safa
  • Kenneth A. Foon
  • Robert K. Oldham


Monoclonal antibodies and their immunoconjugates represent one of the first practical methods for the selective treatment of cancer [42]. Monoclonal antibody technology now allows for the generation of antibodies or ‘cocktails’ of antibodies that have some selectivity for cancer tissue as compared with the normal tissue oforigin. These antibodies can be tested as unconjugated antibody alone or in conjunction with effector cells. The ‘signal strength’ of the antibody may be made more powerful by conjugating antibody to drugs, toxins, biologicals, and radioisotopes with different mechanisms of action and different levels of potency. This chapter will focus on the use of drug immunoconjugates for cancer treatment.


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© Springer Science+Business Media Dordrecht 2003

Authors and Affiliations

  • Malek Safa
  • Kenneth A. Foon
  • Robert K. Oldham

There are no affiliations available

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