Monoclonal antibody therapy

  • Robert O. Dillman


Antibodies represent one of the first forms of targeted therapy that have been successfully applied to cancer treatment [99]. A chronological history of monoclonal antibody development is shown in Table 1. At the end of the 19th century antisera and antibodies were discovered as part of the independent work of Emil Behring and Kitasato Shibegan in developing diphtheria antitoxin. By immunizing an animal with foreign antigens contained on cells, investigators knew they could produce antisera against an antigen. The German immunologist, bacteriologist, and 1908 Nobel Prize winner Paul Ehrlich used the term ‘passive immunization’ to describe the use of antisera and antibodies in the treatment of disease as opposed to the ‘active immunization’ using cell- or antigen-based vaccines. He is generally recognized as the originator of the term ‘magic bullets’ to describe the potential for antibodies to specifically target bacteria or cancer cells as opposed to normal cells [111]. Thus since the early part of the 20th century it has been theorized that antibodies that react with tumor-associated antigens could be effective reagents for the treatment of malignancy.


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© Springer Science+Business Media Dordrecht 2003

Authors and Affiliations

  • Robert O. Dillman

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