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Edible Vaccines in Plants for Livestock Pathogens

  • L. Erickson
  • W-J. Yu
  • T. Tuboly
  • E. Nagy
  • A. Bailey
  • J. Zhang
  • D. Yoo
  • S. Du
Chapter

Abstract

Edible vaccines derived from plants offer clear advantages to the livestock industry with respect to cost and ease of delivery. From a consumer perspective, the widespread adoption by the industry of efficient, low-cost, edible plant-based vaccines offers the prospect of reduced exposure to animal pathogens in food products, as well as in the water supply. A major obstacle encountered in the initial development of plant-based vaccines has been the very low levels of antigens expressed in transgenic plants. Some of the strategies adopted to meet this obstacle include synthetic forms of the antigen genes, fusion proteins and inducible expression systems. However, even with augmented levels of antigen in plant tissue, a successful edible vaccine in plants will probably require in addition strategies for reducing degradation in the gut and enhancing immunogenicity. It may even be possible to develop DNA-based vaccines in plants.

Keywords

oral vaccines transgenic plants synthetic genes antigens porcine swine bovine mucosal immunity virus bacteria intestinal disease 

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Copyright information

© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • L. Erickson
    • 1
  • W-J. Yu
    • 1
  • T. Tuboly
    • 2
    • 3
  • E. Nagy
    • 2
  • A. Bailey
    • 1
  • J. Zhang
    • 1
  • D. Yoo
    • 2
  • S. Du
    • 1
  1. 1.Department of Plant Agriculture, Ontario Agricultural CollegeUniversity of GuelphGuelphCanada
  2. 2.Department of Pathobiology, Ontario Veterinary CollegeUniversity of GuelphGuelphCanada
  3. 3.Department of Microbiology and Infectious DiseasesUniversity of Veterinary SciencesBudapestHungary

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