An Oral Vaccine in Maize Protects Against Transmissible Gastroenteritis Virus in Swine

  • J. Jilka


Transmissible gastroenteritis (TGE) is a highly contagious enteric disease that is characterized by vomiting, severe diarrhea and high mortality in piglets less than two weeks of age. The development of edible vaccines offers the potential to aid in the control of enteric diseases such as TGE. Edible vaccines from plant material could be directly delivered in the feed and could be produced cheaply in large volumes thus avoiding many costs associated with the administration of conventional vaccines. Vaccines from plants are particularly suitable for stimulation of mucosal immunity, since edible plant products can be delivered orally to reach the gut mucosal tissue and elicit an immune response at mucosal surfaces. Recent advances in technology make it now possible to express vaccine antigens at high levels in plants. Corn expressing the S protein of TGEV was fed to 13-day-old piglets for ten days and subsequently challenged with a virulent Purdue strain of TGEV. This group of piglets was significantly protected from the disease as contrasted to the control group that was fed only corn. Results from a second trial duplicated these results demonstrating that the delivery of antigens delivered in an edible oral form are efficacious


antigen mucosal immunity transgenic plants TGEV enteric pathogen 


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Copyright information

© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • J. Jilka
    • 1
  1. 1.Prodigene Inc.TexasUSA

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