Hypertension Caused by other Renal Insults
Various renal injuries have been screened to see if hypertension would result. Two of the most successful: The Page procedure in which the renal capsule is surrounded with an irritating material such as cellophane, and the Grollman procedure in which the renal capsule is compressed by a figure-of-eight ligature. The cause of hypertension and vasoconstriction in these two models remains unclear. Plasma renin activity is not elevated. There is little evidence supporting autoregulatory vasoconstriction. One peculiarity is that unilateral insult must almost always be combined with contralateral nephrectomy before blood pressure will increase. By analogy, the mechanisms involved in the pressure increase may be similar to those that are active in one-kidney Goldblatt hypertension.
KeywordsPlasma Renin Activity External Compression Renal Capsule Venous Compliance Increase Plasma Renin
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