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Growth Factors for Hormone-Sensitive Tumor Cells

  • David A. Sirbasku
  • Frances E. Leland

Abstract

The study of polypeptide growth factor interaction with cells in vitro and in vivo is a rapidly expanding new field of cell biology. Many types of cell growth factors have been identified including the steroid hormones (1), (4), (33), (65), thyroid hormones (49), (62), prostaglandins (24), (25), the classical polypeptide hormones such as insulin (53), (64), and many polypeptide and protein growth factors. Characterization of the polypeptide growth factors such as epidermal growth factor, EGF (14), (22), (51), nerve growth factor, NGF (2), (32), (68), somatomedins (48), (54), (66), fibroblast growth factor, FGF (19), (20), platelet derived growth factor, PDGF (3), (39), (40), (41), (46), and the insulin-like growth factors, IGF1 and IGF2 (17), (18), (45), have provided us with a detailed analysis of the biochemical properties of growth promoting proteins. These pioneering studies have led the way to two important advances in the growth control field. First, they have provided methods for purifying these activities sufficiently to allow their testing as growth regulatory agents on tissues or cell types not previously recognized as target organs. A case in point is the identification of the effects of EGF on mammary cells (5), (6), (34), (67), a growth factor which initially was believed to promote growth of only the epidermal tissues (14), (51), but is now considered important for growth of several cell types in vivo (11), (12), (44). The second major benefit of characterizing these new mitogens was to provide an impetus to other investigators to seek new growth regulatory polypeptides that may be involved in growth of specialized tissue in vivo.

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Copyright information

© Eden Press Inc. 1982

Authors and Affiliations

  • David A. Sirbasku
  • Frances E. Leland

There are no affiliations available

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