Perfluorochemical Emulsions as Blood Substitutes

  • Robert J. Kaufman
Part of the NATO ASI Series book series (ASIC, volume 363)


Perfluorochemicals (PFC’s) dissolve large volumes of oxygen (35–52 vol. %) and carbon dioxide (135–160 vol. %) and are chemically and biochemically inert. These properties have made them candidates for blood substitutes and other therapeutic applications requiring oxygen delivery to tissues. In this paper, the history of PFC’s in medicine and the requirements for a successful commercial emulsion are briefly reviewed. The practical aspects and current status of the production of a safe, shelf stable, small particle size, high PFC content emulsion are reviewed and recent advances in the field such as new PFC’s, novel surfactants, new clinical trials and recent regulatory approvals are presented.


Oxygen Transport Blood Substitute Liquid Ventilation Shock Resuscitation Perfluorocarbon Emulsion 
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Copyright information

© Springer Science+Business Media Dordrecht 1992

Authors and Affiliations

  • Robert J. Kaufman
    • 1
  1. 1.HemaGen/PFCSt. LouisUSA

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