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Effect of an acute inflammatory process on tumour development

  • D. Nolibe
  • I. Florentin
  • M. Pelletier
  • R. Masse
  • J. P. Giroud
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

Since the pioneer work of Metchnikoff it has become well established that a non-immunological inflammation can increase host resistance against infection1. However, little is known about the efffect of such an inflammatory process on anti-tumour defences. Fauve et al. 2 demonstrated that an inflammatory reaction induced in mice by injecting talc particles embedded in a calcium phosphate gel, delayed Lewis carcinoma growth and inhibited metastatic spreading. In the present work, the influence of an acute non-immunological inflammatory reaction induced by an intrapleural injection of an irritant on tumour growth and metastasis of three tumour models in rats and mice has been investigated.

Keywords

Acute Inflammation Inflammatory Stimulus Spontaneous Metastasis Calcium Pyrophosphate Acute Inflammatory Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Fauve, R. M. and Hevin, M. B. (1977). Inflammation et résistance antitumorale. I. Retard de croissance et inhibition du developpement des métastases de la tumeur de Lewis chez des souris porteuses d’une réaction inflammatoire distante d’un site d’inoculation des cellules malignes. Ann. Immunol. (Paris) 128 C, 923Google Scholar
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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • D. Nolibe
    • 1
  • I. Florentin
    • 1
  • M. Pelletier
    • 1
  • R. Masse
    • 1
  • J. P. Giroud
    • 1
  1. 1.France

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