Interaction of inflammatory stimuli: diminished inflammatory response induced by cell accumulation at a distant site (Abstract)
A partial refractory period in polymorphonoculear leukocyte (PMN) emigration during inflammation was demonstrated through sequential stimulation of the rat peritoneal cavity (Lu, W., Scragg, M. A. and Williams, D. M. (1978). Br J. Exp. Pathol. 59, 609): PMN accumulation in response to intraperitoneal injection (IP) of Brain-Heart infusion and proteose peptone (BHI/PP) was depressed by IP glycogen in saline (G) 4 h previously. This reduction may be due to (1) a change in the local endothelium rendering it refractory to a second stimulus; (2) reduced PMN availability in circulating blood; (3) mediators produced in the lesion leading to a local or central inhibition of PMN release or; (4) changes in PMN functional abilities such as adhesion to endothelial wall and chemotaxis.