Advertisement

The effect of an acute inflammatory process on the resistance to infections in mice

  • M. Pelletier
  • M. Parant
  • F. Parant
  • J. M. Jadin
  • L. Chedid
  • J. P. Giroud
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

In 1975 we demonstrated that exudate from acute non-immunological inflammatory reaction could induce DNA synthesis in macrophages in culture1–3. Recently we have shown that during various acute inflammatory processes, macrophages are stimulated and become able to inhibit, in vitro, tumour cell proliferation9. On the other hand, we have shown that acute inflammatory sera are able to modify some cellular functions, in particular:
  1. (1)

    The induction of both DNA synthesis and mitosis in peritoneal macrophages in culture8.

     
  2. (2)

    The inhibition of polymorphonuclear Chemotaxis11.

     
  3. (3)

    The induction of spontaneous DNA synthesis in spleen cells and the modulating response of these cells to PHA7.

     

Keywords

Inflammatory Reaction Listeria Monocytogenes Klebsiella Pneumoniae Trypanosoma Cruzi Inflammatory Exudate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Adolphe, M., Fontagne, J., Pelletier, M. and Giroud, J.P. (1975) Induction of DNA synthesis in rat macrophages in vitro by inflammatory exudate. Nature (London), 253, 637CrossRefGoogle Scholar
  2. 2.
    Adolphe, M., Fontagne, J., Pelletier, M., Giroud, J. P., Timsit, J. and Lechat, P. (1976). Induction of DNA synthesis in rat peritoneal macrophages in culture by a pleural inflammatory exudate. Agents Actions, 6, 114PubMedCrossRefGoogle Scholar
  3. 3.
    Adolphe, M., Fontagne, J., Pelletier, M., Blondelon, D., Lechat, P and Giroud, J. P. (1977). Perspectives in Inflammation, Future Trends and Developments. In Willoughby, D. A., Giroud, J. P. and Velo, G. P. (eds.) Proceedings of the Third International Meeting on Future Trends in Inflammation, p. 469. (Lancaster: MTP Press)Google Scholar
  4. 4.
    Fauve, R. M. and Hevin, B. (1975). Influence d’une réaction inflammatoire sur la résistance de souris à l’infection par Listeria monocytogenes et Salmonella typhimurium. C. R. Acad. Sci., Ser. D., 281, 2037Google Scholar
  5. 5.
    Fauve, R. (1977). Inflammation and host resistance to pathogens. Intensive Care Med., 3, 237PubMedCrossRefGoogle Scholar
  6. 6.
    Fauve, R. M. (1978). Inflammation and host resistance against pathogens in the Pharmacology of Immunoregulation. In Werner, Gitt and Floc’h, F. (eds.) Proceedings of a Rhône-Poulenc Round Table Conference, p. 319. (Academic Press)Google Scholar
  7. 7.
    Florentin, I., Pelletier, M. and Giroud, J. P. (1978). Lymphocyte proliferation induced in vitro by an acute non specific inflammatory exudate. Modulation of the response to phytohe-magglutinin (PHA). Eur. J. Rheumatol. Inflam., 1, 316Google Scholar
  8. 8.
    Giroud, J. P., Pelletier, M. and Girre, C. (1977). Pouvoir mitogene de serums de rats porteurs d’une inflammation aiguë vis-à-vis de macrophages en culture. C. R. Acad. Sci., 285, 1143Google Scholar
  9. 9.
    Kiger, N., Pelletier, M., Florentin, I., Mathe, G. and Giroud, J. P. (1978). Effect of a nonspecific acute inflammatory stimulus on macrophage activation and antibody — dependent -cellular — cytotoxicity. Eur. J. Rheumatol. Inflam., 1, 321Google Scholar
  10. 10.
    Metchnikoff, E. (1905). L’immunité dans les maladies infectieuses. Masson et Cie, p. 315–340Google Scholar
  11. 11.
    Giroud, J.P., Roch-Arveiller, M. and Bradshaw, D. (1978). Modification du chimiotac-tisme des polynucléaires de Rat au cours d’une réaction inflammatoire aiguë. C. R. Acad. Sci., 286, 721Google Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • M. Pelletier
    • 1
  • M. Parant
    • 1
  • F. Parant
    • 1
  • J. M. Jadin
    • 1
  • L. Chedid
    • 1
  • J. P. Giroud
    • 1
  1. 1.France

Personalised recommendations