Effect of flurbiprofen on prostaglandin synthesis (Abstract)

  • V. Kassis
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)


The inhibitory effect of topically applied flurbiprofen, a newer non-steroidal anti-inflammatory agent, on prostaglandin biosynthesis in human skin biopsies in primary irritant dermatitis was examined. The flurbiprofen treated areas synthesized significantly less PGE1 (279 pg/mg dry weight) than placebo treated inflamed skin (626 pg/mg dry weight). The average inhibition in 11 treated patients was 55% (p < 0.01 using Wilcoxon’s signed rank test). Furthermore, when the anti-inflammatory effect of flurbiprofen was clinically evaluated, a poor correlation was found between the reduction of prostaglandin synthesis and the clinical effects of flurbiprofen.


Public Health Clinical Effect Signed Rank Test Skin Biopsy Poor Correlation 
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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • V. Kassis
    • 1
  1. 1.Denmark

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