Effect of flurbiprofen on prostaglandin synthesis (Abstract)
The inhibitory effect of topically applied flurbiprofen, a newer non-steroidal anti-inflammatory agent, on prostaglandin biosynthesis in human skin biopsies in primary irritant dermatitis was examined. The flurbiprofen treated areas synthesized significantly less PGE1 (279 pg/mg dry weight) than placebo treated inflamed skin (626 pg/mg dry weight). The average inhibition in 11 treated patients was 55% (p < 0.01 using Wilcoxon’s signed rank test). Furthermore, when the anti-inflammatory effect of flurbiprofen was clinically evaluated, a poor correlation was found between the reduction of prostaglandin synthesis and the clinical effects of flurbiprofen.