Regulatory mediators in Arthus reactions: demonstration of chemotactic factor inactivator and cell directed inhibitor activity
The study of Arthus reactions has led investigators to a better understanding of the underlying pathogenic mechanism of inflammatory tissue injury evoked by local deposition of complement-activating antigen-antibody complexes. It is well accepted that neutrophils and complement are essential for the mediation of Arthus reactions. In various animal species an Arthus reaction could be inhibited by depletion of the circulating neutrophils with nitrogen mustard1 or specific antiserum2. Depletion of complement with cobra venom factor pretreatment also inhibited Arthus reactions3. The accumulation of neutrophils, which is essential for tissue injury, is probably mediated by complement-derived chemotactic factors. In reversed passive Arthus reactions C5 chemotactic factors could be demonstrated in rat dermis4. Upon intradermal injection into guinea pigs of complement-derived chemotactic factors, accumulation of intravenously administered 51Cr-labelled homlo-gous neutrophils could be observed5.
KeywordsChemotactic Factor Chemotactic Activity Regulatory Mediator Arthus Reaction Passive Arthus Reaction
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