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Levamisole and thymopoietin pentapeptide (TP5) correction of E-rosette depression in man: in vitro and in vivo studies

  • F. Laghi Pasini
  • A. Auteri
  • T. Di Perri
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

Several clinical states may show a decrease of the circulating E-rosette forming cells. We observed that the lymphocytes with a reduced E-rosette forming power when incubated in vitro with levamisole either showed an increase in number to the normal values or the E-rosette forming cells did not change. This last group was less frequent and was found in clinical situations compatible with true thymus-dependent T cell depletion (leukaemia, Hodgkin’s disease, LES). Frequently the incubation of lymphocytes with levamisole was promptly followed by a normalization of the E-rosette forming cells.

Keywords

Rheumatoid Arthritis Rheumatoid Arthritis Patient Thymic Hormone Immunological Defect Thymic Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Di Perri, T., Auteri, A., Laghi Pasini, F. and Mattioli, F. (1978). A weekly oral dose of leva-misole in the treatment of rheumatoid arthritis associated with E-rosette lymphocytes reduction. Eur. J. Rheum. Inflamm., 1,155Google Scholar
  2. 2.
    Di Perri, T., Auteri, A., and Laghi Pasini, F. (1979). Immunokinetics of a single dose of Leva-misole. J. Immunopharm., 1, 269CrossRefGoogle Scholar
  3. 3.
    Di Perri, T., Auteri, A., Laghi Pasini, F. and Mattioli, F. (1979). Action of Levamisole on E-rosette forming cells and serum adenosindeaminase in Hodgkin’s disease. J. Immunopharm., 1,233CrossRefGoogle Scholar
  4. 4.
    Goldstein, G. A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoientin. (unpublished report)Google Scholar
  5. 5.
    Verhaegen, H. Comparison of the in vitro effects of thymopoietin pentapeptide and levamisole on peripheral E-rosette formation, (unpublished report)Google Scholar
  6. 6.
    Boyum, A. (1968). Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest., 21, (Suppl. 97), 77Google Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • F. Laghi Pasini
    • 1
  • A. Auteri
    • 1
  • T. Di Perri
    • 1
  1. 1.Italy

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