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Immunological and clinical effects of human placenta-eluted gammaglobulins (PEGG) in rheumatoid arthritis

  • J. Sany
  • J. Clot
  • M. Bonneau
  • M. Andary
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

The human foetus is considered as an allograft which is accepted by the pregnant mother for still unknown reasons, since humoral and cell mediated responses have been demonstrated against the paternal haplotype2. Autoantibodies to transplantation antigens have been shown in the placenta. After elution at acid pH, Voisin and Chaouat26 have reported that placenta eluates were able specifically to enhance an incompatible graft from paternal tissue. The pioneering work of Revillaed et al. 17 showed that maternal sera contained antibodies that effectively inhibited the mixed lymphocyte reaction (MLR) of maternal cells against paternal lymphocytes. Bonneau et al. 3,4 demonstrated that purified IgG eluted from human placenta were able to inhibit the MLR by blocking HLA-DR antigens carried on stimulating cells18. In addition, these fractions or the F(ab)’2 fragments thereof were shown to prevent the binding of erythrocyte-IgG antibody (EA) complexes to human mononuclear cells.

Keywords

Rheumatoid Arthritis Human Placenta Mixed Lymphocyte Reaction Mixed Lymphocyte Culture Circulate Immune Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • J. Sany
    • 1
  • J. Clot
    • 1
  • M. Bonneau
    • 1
  • M. Andary
    • 1
  1. 1.France

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