Rheumatoid immunoblasts and the effect of gold and cytotoxic drugs
The successful clinical use of thoracic duct drainage1 has confirmed the important role of the lymphocyte in the pathogenesis of rheumatoid arthritis. It is impractical to translate these experimental manoeuvres into a clinical procedure unless the important subgroups of pathogenic lymphocytes can be identified. Activated lymphocytes deserve special attention in this context in view of their known characteristics. Activated lymphocytes with the morphological appearance of immunoblasts have previously been identified in increased numbers in rheumatoid arthritis2 and shown to be large cells with an increased thymidine uptake.
KeywordsRheumatoid Arthritis2 Ficoll Gradient Gold Therapy High Density Fraction Rheumatoid Synovitis
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