Different susceptibilities to 4-hydroperoxycyclophosphamide of T cell sub-sets involved in delayed-type hypersensitivity of mice to sheep red blood cells

  • S. H. E. Kaufmann
  • H. Hahn
  • T. Diamantstein
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)


It has been amply shown that cyclophosphamide (Cy), in addition to its immunosuppressive properties, enhances the cellular immune response to heterologous red blood cells, and both elimination by Cy of B cells and suppressor T cells (Ts cells) have been postulated as the underlying mechanism1–3. 4-hydroperoxycyclophosphamide (4-HPCy) is a derivative of Cy which in contrast to Cy acts on lymphocytes in vitro since the compound in aqueous solution is converted to 4-hydroxycyclophosphamide, the naturally occurring metabolite of Cy4.


Spleen Cell Cell Transfer Recipient Mouse Relative Susceptibility Hind Footpad 
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  1. 1.
    Lagrange, P. H., Mackaness, G. B. and Miller, T. E. (1974). J.Exp. Med., 139,1529PubMedCrossRefGoogle Scholar
  2. 2.
    Ramshaw, I. A., Bretscher, P. A. and Parish, C. R. (1976). Eur.J.Immunol., 6, 674PubMedCrossRefGoogle Scholar
  3. 3.
    Kaufmann, S. H. E., Ahmed, J. S., Chahin, M., and Hahn, H. (1979). Immunology, 38,613PubMedGoogle Scholar
  4. 4.
    Shand, F. L. and Howard, J. G. (1979). Eur.J.Immunol., 9,17PubMedCrossRefGoogle Scholar
  5. 5.
    Hahn, H., Kaufmann, S. H. E., Miller, T. E. and Mackaness, G. G. (1979). Immunology, 36, 691PubMedGoogle Scholar
  6. 6.
    Hahn, H., Kaufmann, S. H. E., Falkenberg, F., Chahin, M. and Horn, W. (1979). Immunology, 38, 51PubMedGoogle Scholar
  7. 7.
    Askenase, P. W., Hayden, B. J. and Gershon, R. K. (1975). J.Exp.Med., 141, 697PubMedCrossRefGoogle Scholar
  8. 8.
    Ramshaw, P. A., Bretscher, P. A., and Parish, C.R. (1977). Eur.J.Immunol., 7,180PubMedCrossRefGoogle Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • S. H. E. Kaufmann
  • H. Hahn
  • T. Diamantstein

There are no affiliations available

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