Interaction of macrophages and synthetic polyanions in the inflammatory response
Polyanions are, within the immunological field, of considerable interest. They exert a variety of functions on both humoral and cellular levels. Dextran sulphate (DS), for example, is known to activate the alternative pathway of complement1,2 and interacts with components of the classical pathway3,4. It is known to replace T cell function and to trigger B cell activation5,6. In addition, polyanions gained interest because of their macrophage activating effect7,8 and their anti-viral and anti-tumour activity9,10. In previous publications we described a relationship of the capacity of some polyanions such as carragee-nins or dextran sulphates of different molecular weights and degrees of sul-phation to induce chronic inflammatory responses in vivo, to activate macrophages so that they secrete enzymes and kill tumour cells7,11,12.
KeywordsLysosomal Enzyme Enzyme Secretion Mouse Peritoneal Macrophage Dextran Sulphate Acid Hydrolase
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