Technetium-99m labelled leukocytes: preparation, animal studies and potential application

  • N. Linhart
  • B. Bok
  • M. Meignan
  • M. Gougerot
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)


Several authors have used labelled phagocytes to detect inflammatory foci in cases of infection2,3. 51Cr was the first marker used but its high photon energy and long physical half-life are obvious drawbacks4. Other gamma emitters such as 67Ga have also been suggested for human leukocyte labelling5 and for direct intravenous administration in abscess detection.


High Photon Energy Inflammatory Focus Metabolic Test Phagocytic Leukocyte Radioactive Agent 
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  1. 1.
    Linhart, N., Bok, B., Gougerot, M., Gaillard, M.T., Meignan, M. (1979). Te 99m labelled human leukocytes: an in vitro functional study, Acta Haematol. Google Scholar
  2. 2.
    Mc Afee, J. G. and Thakur, M. L. (1976). Survey of radioactive agents form vitro labeling of phagocytic leukocytes. I. Soluble agents. J. Nucl. .Med 17,480Google Scholar
  3. 3.
    Mc Afee, J. G., and Thakur, M. L. (1976). Survey of radioactive agents for in vitro labeling of phagocytic leukocytes. II, Particles. J. Nucl. .Med, 17, 488Google Scholar
  4. 4.
    Dresch, C. and Najean, Y. (1967). Étude de la cinétique des polynucléaires après marquage ‘in vitro’ par le radiochrome. Étude critique de la méthode et résultats obtenus chez les sujets normaux. Nouv. Rev. Fr. Hematol., 7,17Google Scholar
  5. 5.
    Biello, D. R., Levitt, R. G. and Leland Melson, G. (1979). The roles of Gallium — 67 Scintigraphy, Ultrasonography, and computed tomography in the detection of abdominal abscesses. Semin. Nucl. .Med, 9,Google Scholar
  6. 6.
    Cutler, J. E. (1974). A simple in vitro method for studies on Chemotaxis. Proc. Soc. Exp. Biol. .Med, 147,471PubMedGoogle Scholar
  7. 7.
    Feliu, E., Gougerot, M. A., Hakim, J., Cramer, E., Auclair, C., Rueff, B., and Boivin, P. (1977). Blood polymorphonuclear dysfunction in patients with alcoholic cirrhosis. Eur. J. Clin. Invest., 7,571PubMedCrossRefGoogle Scholar
  8. 8.
    Gray, H. W., Tsan, M.F. and Wagner, FL N., Jr (1977).Aquantitativestudyofleukocyteco-hesion. Effects of divalent cations and pH. J. Nucl. .Med, 18,147PubMedGoogle Scholar
  9. 9.
    Thakur, M.L., Segal, A. W., Louis, L., Welch, M.J. and Peters, T.J. (1977). Indium 111 labeled cellular blood components: mechanism of labeling with special reference to studies with human neutrophils. J. Nucl. .Med, 18, abstract 619Google Scholar
  10. 10.
    Parmentier, C., Chavaudra, J. and Meignan, M. (1978). Dose received by lymphocytes in the course of labeling techniques using Tc 99m. J. Nucl. .Med, 19,223PubMedGoogle Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • N. Linhart
    • 1
  • B. Bok
    • 1
  • M. Meignan
    • 1
  • M. Gougerot
    • 1
  1. 1.France

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