β2-Microglobulin, anti-β2-microglobulin activity and circulating immune complexes in rheumatoid arthritis: seric and synovial studies
The elevation of serie β2-microglobulin (β2m) levels is well known in inflammatory diseases5,20. The exact role β2m plays is not so clear. It is present on the surface of nucleated cells and platelets, bound to HL-A, to form the light chain of it. Moreover, its amino acid sequence shows a high degree of homology with domains of human IgG (CH3). These two properties are the main reasons for the interest of the detection of β2m in autoimmune diseases. Michalski10 and Talal19 show the elevation of salivary and synovial β2m levels in Sjöngren’s syndrome and rheumatoid arthritis (RA), in relation with the illness. According to these authors, the elevation of β2m indicates local production in the tissue, especially salivary tissue. Ström18 only found such results in 38% of sicca syndrome. In systemic lupus erythematosus (SLE), Revillard16, by using a precipitation of radio-labelled β2m in polyethylene glycol, showed a β2m binding activity significantly higher than in control sera. Ooi12 detected this activity by using a double antibody assay. Finally Mani-court Brauman8 and Orloff13 detected high levels of serie and synovial β2m in R. A., in correlation with joint count and the erythrocyte sedimentation rate (ESR). In a recent work, Manicourt9 points out the fact that there is a correlation between β2m and complement components. For these authors, the elevation of β2m would be due to lymphocyte infiltration in synovial tissue.
KeywordsRheumatoid Arthritis Systemic Lupus Erythematosus Rheumatoid Arthritis Patient Immune Complex Rheumatoid Arthritis Group
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