Serum and synovial fluid ferritin in rheumatoid arthritis
Anaemia commonly follows any chronic inflammatory condition. The causes are complex and centred around alterations in iron kinetics1,2. In patients with rheumatoid arthritis, studies using 59Fe-labelled transferrin suggest that intravenously injected iron is utilized in a normal manner and incorporated into circulating erythrocytes3. However, in chronic inflammatory states, defective utilization of iron from senescent erythrocytes has been shown using 59Fe-labelled cells4 and studies with 59Fe-labelled dextran implicates reticuloendothelial cell dysfunction as the cause5. The excess iron stored within the RE cell is reflected by a rise in the serum ferritin.
KeywordsRheumatoid Arthritis Synovial Fluid Serum Ferritin Ferritin Level Serum Ferritin Level
Unable to display preview. Download preview PDF.
- 7.Allison, N. and Chorley, R. K. Diagnosis in Joint Disease. A Clinical and Pathological Study of Arthritides. 193. (New York: Wood)Google Scholar
- 8.Ritchie, D.M., Boyle, J. A., Mclnnes, J.R., Jasani, K.M., Dalabos, T.C., Grieveson, P. and Buchanan, W. W. (1968). Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. J. Med., 147,393Google Scholar
- 10.Muirden, K. D. (1970). The anaemia of rheumatoid arthritis: The significance of iron deposits in the synovial membrane. Aust. Ann. Med., 2,97Google Scholar
- 12.Papadimitriou, G., Bacon, P. A., Carter, S. D. and Hall, N. D. (1980) Rheumatoidimmuno-blasts and the effect of gold and cytotoxic drugs. This volume, Chap. 80Google Scholar