Diverging effects of chemotactic serum peptides and synthetic f-Met-Leu-Phe on neutrophil locomotion and adhesion (Abstract)
The chemotactic serum peptides CAT 1.6.1. and C5adesArg induced marked directional locomotion over a wide concentration range. They had, however, no significant effects on random locomotion and adhesion of human neutrophils. In contrast, f-Met-Leu-Phe produced marked negative chemokinetic effects and its capacity to induce directional locomotion was more limited with respect to magnitude and concentration range. Migration inhibition as induced by f-Met-Leu-Phe was related to its dose-dependent effects on spreading and cell adhesion. The results suggested that chemotactic serum peptides are more suitable than f-Met-Leu-Phe to study reactions which are specifically related to Chemotaxis, at least under the test conditions used.