Modification of Chemotaxis and peptide binding during pathophysiological state of polymorphonuclear leukocytes
Local recruitment of polymorphonuclear leukocytes (PMNs) to inflammatory sites is essential to the host in its defence against injury. The activation of directed migration of cells (Chemotaxis) along a chemical gradient is determined by a variety of attractants such as serum factors1, particularly a fragment of the fifth component of complement2, bacterial metabolites3, cell derived materials from sensitized lymphocytes4, or PMNs and denatured proteins5. Recently Schiffman et al. 6 have shown that small synthetic N-formyl-methionyl peptides, which may be related to natural bacterial leukoattractants, induce leukocyte Chemotaxis. Williams et al. 7 with human PMNs and Aswanikumar et al. 8, with rabbit PMNs have demonstrated that membrane receptors appear to mediate Chemotaxis induced by both natural bacterial peptides and formylated synthetic peptides.
KeywordsMigration Inhibitory Factor Peptide Binding Boyden Chamber Human Polymorphonuclear Leukocyte Calcium Pyrophosphate
Unable to display preview. Download preview PDF.
- 1.Keller, H. U. and Sorkin, E. (1966). Studies on Chemotaxis. IV The influence of serum factors on granulocyte locomotion. Immunology, 10, 409Google Scholar
- 9.Bessis, M. (1974). Necrotaxis, Chemotaxis towards an injured cell. Antibiot. Chemother. (Basel) 19, 369Google Scholar
- 10.Giroud, J.P., Roch-Arveiller, M. and Muntaner, O. (1978). Prélèvement répété des polynucléaires dans la cavité pleurale du rat. Application à l’étude du chimiotactisme. Nelle Rev. Fse. Hématol., 20, 535Google Scholar
- 14.Ward, P. A. and Becker, E. L. (1968). The deactivation of rabbit neutrophils by chemotactic factor and the nature of the activariable esterase. J. Exp. Med., 127,Google Scholar