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Observations on the influence of anti-oxidant compounds on prostaglandin biosynthesis (Abstract)

  • M. V. Torrielli
  • J. S. Franzone
  • T. Natale
  • R. Cirillo
  • L. Sena
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

A number of anti-oxidant agents and/or free radical scavengers exert an antiinflammatory activity that is displayed in various models of acute and chronic experimental inflammation in diverse fashion1. Three of the most active compounds for preventing acute inflammatory reactions appear to be propyl gallate (PG), 2-mercaptopropionylglycine (2MPG) and N,N’-diphenyl-p-phenylendiamine (DPPD). These chemicals significantly depress hind paw oedema induced acutely in the rat by injection of carrageenin, bradykinin, serotonin or dextran. In addition, PG and 2MPG are able to restrict, respectively, the phlogistic process following the injection of 4-hydroxy-2, 3-trans-penten-1-al and malealdehyde, while some non-steroidal anti-inflammatory agents are ineffective. The aldehydes mentioned above are thought to be among the final products of lipid peroxidation. An interpretation of the mechanisms of action of the above chemicals derives from data showing that lipid peroxidation plays a role in inflammation. Furthermore, such compounds could act by inhibiting the production of endoperoxides during the biosynthesis of prostaglandins. Recently, the pivotal role of PGE2 in inflammation has been stressed2.

Keywords

Lipid Peroxidation Salicylic Acid Arachidonic Acid Pivotal Role Antiinflammatory Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Dianzani, M. U., Torrielli, M. V., Paradisi, L. and Franzone, J. S. (1978). Eur. J. Rheum. Inflamm., 1, 187Google Scholar
  2. 2.
    Kuehl, F. A., Humes, J. L., and Egan, R. (1977). In Willoughby, D. A., Giroud, J.P. and Velo, G. P. (eds.) Perspectives in Inflammation p. 331 (Lancaster: MTP Press)Google Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • M. V. Torrielli
    • 1
  • J. S. Franzone
    • 1
  • T. Natale
    • 1
  • R. Cirillo
    • 1
  • L. Sena
    • 1
  1. 1.Italy

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