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Specificity of glucocorticoid inhibition of synovial prostaglandin synthesis

  • R. M. McMillan
  • Constance E. Brinckerhoff
  • Edward D. HarrisJr.
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

Inhibition of prostaglandin (PG) synthesis contributes to the antiinflammatory activity of a number of anti-rheumatic compounds. Inhibition of PG synthesis by non-steroidal anti-inflammatory drugs (e.g. aspirin, indomethacin) has been observed in experiments with cell-free preparations of PG synthase as well as in intact tissues and cells1–3. These agents appear to act primarily by blocking the enzyme cylo-oxygenase which catalyses the initial step in synthesis of PGs from their fatty acid precursor, arachidonic acid4.

Keywords

Phorbol Myristate Acetate Synovial Fibroblast Synovial Cell Phorbol Myristate Acetate Fatty Acid Precursor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • R. M. McMillan
    • 1
  • Constance E. Brinckerhoff
    • 1
  • Edward D. HarrisJr.
    • 1
  1. 1.USA

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