Inhibitory effect of benoxaprofen and BW 755C on rabbit PMN leukocyte lipoxygenase (Abstract)

  • J. R. Walker
  • W. Dawson
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)


Arachidonic acid is metabolized by rabbit peritoneal PMNs via both prostaglandin cyclo-oxygenase and fatty acid lipoxygenase pathways to yield a multiplicity of biologically active products. These activities have been well characterized for the prostaglandins and thromboxanes and recent attention has been directed to the activities of the many hydroxy substituted arachidonic acid metabolites including leukocyte chemotactic and chemokinetic stimulation and possible mediation of leukoctye aggregation1,2.


Arachidonic Acid Active Product Treatment Mation Acid Metabolite Calcium Ionophore 
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    Goetzl, E. J. and Sun, F. F. (1979). J. Exp. Med. 150, 406PubMedCrossRefGoogle Scholar
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    Ford-Hutchinson, A. W., Bray, M. A. and Smith, M. J. H. (1979). J. Pharm. Pharmacol, 31, 868PubMedCrossRefGoogle Scholar
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    Higgs, G., Flower, R.J. and Vane, J. R. (1979). Biochem. Pharmacol., 28, 1959PubMedCrossRefGoogle Scholar
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    Walker, J. R. and Dawson, W. (1979). J. Pharm. Pharmacol., 31, 778PubMedCrossRefGoogle Scholar

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • J. R. Walker
    • 1
  • W. Dawson
    • 1
  1. 1.UK

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