Influence of colchicine derivatives on lysosomal enzyme release from polymorphonuclear leukocytes and intracellular levels of cAMP after phagocytosis of monosodium urate crystals

  • Daniela Mikulíková
  • Karel Trnavský
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)


Colchicine and its analogues belong to the group of microtubular inhibitors1. Microtubules are involved in the transport of extracellular material wrapped in vesicles towards lysosomes. Drug-induced tubulostasis may lead to reduced digestion of phagocytozed material and could prevent metabolic transformation of this material. These events possibly play a role in the inhibition of the generation of inflammatory mediators2. Colchicine does not stabilize isolated lysosomes3 and so its primary action on polymorphonuclear functions (release of lysosomal enzymes and chemotactic factors, motility etc.) is possibly mediated through its anti-microtubular activity4.


Lysosomal Enzyme Enzyme Release Acute Gout Urate Crystal Calcium Pyrophosphate 
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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • Daniela Mikulíková
    • 1
  • Karel Trnavský
    • 1
  1. 1.Czechoslovakia

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