Mycoplasmas stimulate mouse peritoneal macrophages to secrete lysosomal enzymes and to be cytotoxic
The pathogenic mechanisms in mycoplasma infections are not fully understood. Several mechanisms may contribute to the recovery of animals from mycoplasma infections and resistance to reinfections. A feature of mycoplasma infections in the lungs and other sites is the associated mononuclear cell reaction. The infiltrating cells belong mainly to the lymphocyte and macrophage series. In bronchiolar exudates of mice infected with M.pulmonis 1,2 and hamsters infected with M.pneumoniae, macrophages are common. Serum antibodies transferred from mice recovering from pneumonia to recipient mice provides some protection against the development of pneumonia in these animals following inoculation of M.pulmonis 3. According to the well-known view of Mackaness4, immunity to infectious bacteria has two components.
KeywordsMigration Inhibitory Factor Lysosomal Enzyme Acid Hydrolase Macrophage Culture Mycoplasma Infection
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