Early lymphocyte activation and proliferative response induced by lectins: individual variations in man
An immunological inbalance was recently claimed in most of inflammatory rheumatic diseases, such as rheumatoid arthritis1, SLE2,3, ankylosing spondylitis and Reiter’s syndrome4–6. Several methods were used but the criteria to assess immunological deficiency are not yet standardized. However, therapeutic use of immunomodulator drugs needs standardized criteria to show their action in patients. Therefore, we chose two tests to study the function of lymphocytes: early lymphocyte activation of the nucleus by the refringence test7–9 and late lymphocyte activation by proliferative response ([3H]thymidine incorporation).
KeywordsSystemic Lupus Erythematosus Proliferative Response Thymidine Incorporation Lymphocyte Activation Lymphocyte Response
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