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‘L’ lymphocytes, immune complexes and the amplification of human T lymphocyte proliferation

  • D. A. Horwitz
  • E. M. Carvalho
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

Immune complexes have an important role in the regulation of the immune response. IgG complexed to specific antigen can enhance or suppress lymphocyte proliferation in vitro. We have focussed our attention on augmentation of lymphocyte proliferation and have described the conditions required for enhancement by immune complexes, identified the lymphocyte population mediating this effect and have described a mechanism of action1,2. These studies will be summarized in this report. We will show that ‘L’ lymphocytes amplify T cell proliferation. ‘L’ lymphocytes are the C3 receptor negative sub-set of non-T non-B cells and comprise approximately 10% of blood lymphocytes in healthy individuals. The surface markers and functional properties of L cells have been well characterized3,4.

Keywords

Immune Complex Lymphocyte Proliferation Keyhole Limpet Haemocyanin Unstimulated Culture Lymphocyte Blastogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Carvalho, E. M., Davis, J. S. and Horwitz, D. A. (1979). Conditions required for Fc-dependent immune complex enhancement of antigen-specific lymphocyte blastogenesis. J. Immunol, 124, 565Google Scholar
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    Carvalho, E. M. and Horwitz, D. A. (1980). Characterization of a non-T, non-B human blood lymphocyte that mediates the enhancing effects of immune complexes on lymphocyte blastogenesis. J. Immunol, 124,437Google Scholar
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    Horwitz, D. A., Niaudet, M. F., Greaves, J. D. and Deteix, P. (1978). Surface markers and electron microscopy of human blood L cells: a comparison with T and B lymphocytes. J. Immunol, 121, 678PubMedGoogle Scholar
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Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • D. A. Horwitz
    • 1
  • E. M. Carvalho
    • 1
  1. 1.USA

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