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Enkephalins and the immune system (Abstract)

  • J. Wybran
  • T. Appelboom
  • A. Govaerts
  • J. P. Famaey
Part of the Inflammation: Mechanisms and Treatment book series (FTIN, volume 4)

Abstract

This study reports the in vitro influence of morphine, dextromoramide, levo-moramide and methionine-enkephalin upon normal human T blood lymphocytes by using the active and total rosette tests, Morphine and dextromoramide inhibited the percentage of active T rosettes. This effect was completely reversed in the presence of naloxone, their specific antagonist. The specificity was further demonstrated by the absence of the effect of levo-moramide, the inactive enantiomere, upon the rosette system. Methionine-enkephalin increased the percentage of active T rosettes. This effect was specifically inhibited by naloxone. These observations suggest that normal human blood T lymphocytes bear surface receptor-like structures for morphine, dextromoramide and methionine-enkephalin. Since non-opiate receptors have also been described on B lymphocytes, the ‘two hits opioid lymphocyte receptor hypothesis’ is presented. This theory postulates that opioid peptides can modulate the co-operation between T and B lymphocytes. Finally, such findings may provide a link betweeen the central nervous system and the immune system, and enkephalins may be the humoral mediators between the two systems.

Keywords

Public Health Nervous System Central Nervous System Immune System Human Blood 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© MTP Press Limited 1980

Authors and Affiliations

  • J. Wybran
    • 1
  • T. Appelboom
    • 1
  • A. Govaerts
    • 1
  • J. P. Famaey
    • 1
  1. 1.Belgium

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