Spinal, Supraspinal and Peripheral Sites of Opioid Intestinal Actions
Opioid agonists, administered systemically, induce profound changes in gastrointestinal contractile and propulsive activity. It has now become apparent that opioids can exert effects at multiple sites within the body with different intestinal motility consequences. Also, the recognition of multiple subtypes of opioid receptors and the multiplicity of receptor actions of individual opioid agonists has recently provided new tools for the identification of sites and mechanisms of opioid actions affecting motility (1,2). It was our purpose to explore systematically the roles of brain, spinal cord, intramural neuron and smooth muscle components of opioid actions that influence gastrointestinal motility.
KeywordsOpioid Receptor Gastrointestinal Motility Intestinal Transit Opioid Agonist Delta Opioid Receptor
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