Central Effects of Thyrotropin-Releasing Hormone on Gastrointestinal Motility in Fasted and Fed Rats
Many actions on gastrointestinal functions(1–6) have been demonstrated for TRH since it has been located in the gastrointestinal tract(7). Excitatory effects of TRH on duodenal and colonic motilities in anaesthetized rabbits(8,9) and rats(10) have been related to central administration of the peptide. Preliminary results have shown that small doses of TRH inactive under anaesthesia when given by intracerebroventricular (ICV) and intravenous (IV) routes, have induced an hyperactivity of the gastroduodenal junction at a dosage of 1 (ICV) to 5 (IV) in the conscious animal. We have examined, therefore, the effects on the patterns of small intestine electrical activity of an ICV vs. IV administration of TRH in conscious rats, either fasted or fed, under anaesthesia and after different pretreatments.
KeywordsGastrointestinal Motility Colonic Motility Dopamine Antagonist Conscious Animal Motor Profile
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