The Interaction of Adenosine with Isolated Myenteric Nerve Varicosities
Adenosine and related compounds are presynaptic inhibitors of acetylcholine release from nerve endings in the myenteric plexus (1,2,3). This inhibition is probably mediated by specific cell-surface receptors (4) and the possibility that they mediate physiological neuro-modulation at nerves in the plexus has been suggested (5).
KeywordsAdenosine Deaminase Gastrointestinal Motility Myenteric Plexus Acetylcholine Release Scatchard Plot
Unable to display preview. Download preview PDF.
- 4.Okwuasaba, F.K., Hamilton, J.T. and Cook, M.A. (1978). Evidence for the Cell Surface Locus of Presynaptic Purine Nucleotide Receptors in the Guinea-pig Ileum. J. Pharmacol. Exp. Ther. 207, 779–786.Google Scholar
- 5.Fredholm, B.B., Gustafsson, L.E., Hedqvist, P. and Solleri, A. (1983). Adenosine in the regulation of neurotransmitter release in the peripheral nervous system. In: Berne, R.M., Rall, T.W. and Rubio, R. (eds.). Regulatory Function of Adenosine. pp. 479–495 ( Boston: Martinus Nijhoff ).CrossRefGoogle Scholar
- 7.Newman, M. and Levitzki, A. (1982). Characteristics of high-affinity [3H]-adenosine binding to rat brain synaptosomes and turkey erythrocyte membranes. Biochem. Biophys. Acta. 685., 129–136.Google Scholar
- 8.Cook, M.A., Hamilton, J.T. and Okwuasaba, F.K. (1979). Structure-Activity Relationship Studies of Purinergic Agonists: Some speculations on the Source and Identity of the Purinergic Mediator. In: Baer, H.P. and Drummond, G.I. (eds). Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides. pp. 103–113 ( New York, Raven Press ).Google Scholar
- 12.White, T.D. and Leslie, R.A. (1982). Depolarization-induced release of adenosine 5-triphosphate from isolated varicosities derived from the myenteric plexus of the guinea-pig small intestine. J. Neuroscience 2, 206–215.Google Scholar