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Facilitation and Inhibition by 5-Hydroxytryptamine and R 51 619 of Acetylcholine Release from Guinea Pig Myenteric Neurones

  • I. Pfeuffer-Friederich
  • H. Kilbinger

Abstract

Electrophysiological (North et al., 1980) and neurochemical (Kilbinger and Pfeuffer-Friederich, 1982; Pfeuffer-Friederich and Kilbinger, 1983) experiments have shown that the cholinergic nerves of the guinea pig myenteric plexus are endowed with two types of 5-hydroxytryptamine (5-HT) receptors: 1. Exitatory receptors whose stimulation leads to an increased release of acetylcholine (ACh). This receptor is stimulated by 5-HT and by metoclopramide. It has been suggested that the increase by metoclopramide of smooth muscle contraction of the guinea pig ileum is related to the release of ACh (Kilbinger et al., 1982). 2. Inhibitory receptors whose activation by 5-HT or by LSD causes an inhibition of ACh release evoked by electrical stimulation of the myenteric plexus. The inhibitory receptor can be specifically blocked by methysergide and by methiothepine (Kilbinger and Pfeuffer-Friederich, 1982; Pfeuffer-Freiderich and Kilbinger, 1983).

Keywords

Gastrointestinal Motility Myenteric Plexus Acetylcholine Release Field Stimulation Cholinergic Nerve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© MTP Press Limited 1984

Authors and Affiliations

  • I. Pfeuffer-Friederich
  • H. Kilbinger

There are no affiliations available

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