Correlation between the Electrical Properties and Morphological Characteristics in the Smooth Muscle Cells during Culture
Electrophysiological properties of smooth muscle cells have been extensively studied in various smooth muscle tissues. These distinct membrane properties of smooth muscle cells are based on the studies of organic tissues. Studies on the electrical properties of the smooth muscle cells from intact tissues raise certain problems because of the neural elements within the tissues, and because of the low electrical coupling between the smooth muscle cells. Furthermore, the presence of diffusion barriers and the intercellular current make it impossible to measure accurately the electrical properties of a single smooth muscle cell. To overcome such problems, researchers have described electrophysiological measurements on the cultured smooth muscle cell in vitro (1, 2, 3, 4 and 5). We re-investigated the cultured smooth muscle cells from guinea-pig taenia coli to elucidate the electrical properties of cultured smooth muscle cells.
KeywordsSmooth Muscle Cell Gastrointestinal Motility Smooth Muscle Tissue Spontaneous Action Potential Spontaneous Electrical Activity
Unable to display preview. Download preview PDF.
- 2.Purves, R.D. (1974). Muscarinic excitation: a microelectrophoretic study on cultured smooth muscle cells. Br. J. Pharmac., 52, 77–86.Google Scholar
- 4.Kimes, B.W. and Brandt, B.L. (1976). Characterization of two putative smooth muscle cell lines from rat thoracic aorta. Expl. Cell Res., 98, 336–347.Google Scholar
- 16.Tornita, T. (1981). Electrical activity (spikes and slow waves) in gastrointestinal smooth muscles. In: Bülbring, E., Brading, A. F., Jones, A. W. and Tornita, T. Ed. Smooth muscle: an assessment of current knowledge. pp. 127–156. (london: Edward Arnold)Google Scholar