Effects of Pancreatic Polypeptide, NPY and PYY in Relation to Sympathetic Influence on Colonic Motility and Blood Flow

  • P. M. Hellström
  • O. Olerup
  • K. Tatemoto


The neuropeptide Y (NPY) and the peptide YY (PYY) have been isolated from the brain and intestine, respectively (1,2). NPY and PYY have 36 amino acid residues and possess structural similarities with pancreatic polypeptide (PP) (1). Sympathetic noradrenergic neurons contain NPY-like immunoreactivity (3). Recently, it has been shown that NPY may be responsible for the sympathetic vasoconstriction resistant to α-adrenoceptor blockade (4). Thus, it is suggested that NPY may act as a sympathetic neurotransmitter. PYY-like immunoreactivity is localized to endocrine cells in the mucosa of mammalian distal intestine. PYY causes vasoconstriction and inhibition of colonic motility (5).


Nerve Stimulation Distal Colon Gastrointestinal Motility Pancreatic Polypeptide Splanchnic Nerve 
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  1. 1.
    Tatemoto, K. (1982). Isolation and characterization of peptide YY (PYY) a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc. Natl. Acad. Sci., 79, 2514–2518PubMedCrossRefGoogle Scholar
  2. 2.
    Tatemoto, K., Carlquist, M. and Mutt, V. (1982). Discovery and isolation of neuropeptide Y ( NPY), a brain peptide that has structural similarities to intestinal PYY and the pancreatic polypeptide. Nature, 296, 659–660PubMedCrossRefGoogle Scholar
  3. 3.
    Lundberg, J.M., Terenius, L., Hökfelt, T., Martling, C.R., Tatemoto, K., Mutt, V., Polak, J., Bloom, S.R. and Goldstein, M. (1982). Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol. Scand., 116, 477–480PubMedCrossRefGoogle Scholar
  4. 4.
    Lundberg, J.M. and Tatemoto, K. (1982). Pancreatic polypeptide family (APP, BPP, NPY and PYY) in relation to sympathetic vasoconstriction resistant to a-adrenoceptor blockade. Acta Physiol. Scand. 116, 393–402PubMedCrossRefGoogle Scholar
  5. 5.
    Lundberg, J.M., Tatemoto, K., Terenius, L., Hellström, P.M., Mutt, V., Hökfelt, T. and Hamberger, B. (1982). Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility. Proc. Natl. Acad. Sci., 79, 4471–4475PubMedCrossRefGoogle Scholar
  6. 6.
    Fredholm, B.B. (1976). Release of adenosine-like material from isolated perfused dog adipose tissue following sympathetic nerve stimulation and its inhibition by adrenergic a-receptor blockade. Acta Physiol. Scand. 96, 422–430CrossRefGoogle Scholar
  7. 7.
    Fredholm, B.B. and Hedqvist, P. (1978). Release of (3H)-purines from (3H)-adenine labelled rabbit kidney following sympathetic nerve stimulation and its inhibition by a-adrenoceptor blockade. Br. J. Pharmacol., 64, 239–245PubMedGoogle Scholar
  8. 8.
    Sundler, F., Moghimzadeh, E., Hâkanson, R., Ekelund, M. and Emson, P. (1983). Nerve fibres in the gut and pancreas of the rat displaying neuropeptide-Y immunoreactivity. Cell Tissue Res., 230, 487–493PubMedCrossRefGoogle Scholar

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© MTP Press Limited 1984

Authors and Affiliations

  • P. M. Hellström
  • O. Olerup
  • K. Tatemoto

There are no affiliations available

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