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Effects of Pancreatic Polypeptide, NPY and PYY in Relation to Sympathetic Influence on Colonic Motility and Blood Flow

  • P. M. Hellström
  • O. Olerup
  • K. Tatemoto

Abstract

The neuropeptide Y (NPY) and the peptide YY (PYY) have been isolated from the brain and intestine, respectively (1,2). NPY and PYY have 36 amino acid residues and possess structural similarities with pancreatic polypeptide (PP) (1). Sympathetic noradrenergic neurons contain NPY-like immunoreactivity (3). Recently, it has been shown that NPY may be responsible for the sympathetic vasoconstriction resistant to α-adrenoceptor blockade (4). Thus, it is suggested that NPY may act as a sympathetic neurotransmitter. PYY-like immunoreactivity is localized to endocrine cells in the mucosa of mammalian distal intestine. PYY causes vasoconstriction and inhibition of colonic motility (5).

Keywords

Nerve Stimulation Distal Colon Gastrointestinal Motility Pancreatic Polypeptide Splanchnic Nerve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MTP Press Limited 1984

Authors and Affiliations

  • P. M. Hellström
  • O. Olerup
  • K. Tatemoto

There are no affiliations available

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