Effects of Pancreatic Polypeptide, NPY and PYY in Relation to Sympathetic Influence on Colonic Motility and Blood Flow
The neuropeptide Y (NPY) and the peptide YY (PYY) have been isolated from the brain and intestine, respectively (1,2). NPY and PYY have 36 amino acid residues and possess structural similarities with pancreatic polypeptide (PP) (1). Sympathetic noradrenergic neurons contain NPY-like immunoreactivity (3). Recently, it has been shown that NPY may be responsible for the sympathetic vasoconstriction resistant to α-adrenoceptor blockade (4). Thus, it is suggested that NPY may act as a sympathetic neurotransmitter. PYY-like immunoreactivity is localized to endocrine cells in the mucosa of mammalian distal intestine. PYY causes vasoconstriction and inhibition of colonic motility (5).
KeywordsNerve Stimulation Distal Colon Gastrointestinal Motility Pancreatic Polypeptide Splanchnic Nerve
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- 3.Lundberg, J.M., Terenius, L., Hökfelt, T., Martling, C.R., Tatemoto, K., Mutt, V., Polak, J., Bloom, S.R. and Goldstein, M. (1982). Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol. Scand., 116, 477–480PubMedCrossRefGoogle Scholar