In Vitro Study of the Effects of Leu-Enkephalin and Related Drugs on the Vagally Induced Responses of the Cat Lower Esophageal Sphincter

  • A. Jean
  • J. P. Miolan
  • C. Roman


The lower esophageal sphincter (LES) has a double extrinsic innervation (parasympathetic and sympathetic). The parasympathetic pathway running in the vagus nerves is composed of cholinergic preganglionic fibers connected either with excitatory cholinergic intramural neurons or with inhibitory non-adrenergic non-cholinergic neurons (1, 2). In physiological conditions the inhibitory vagal pathway is involved in the LES opening during swallowing and secondary esophageal peristalsis; the excitatory vagal pathway probably participates in the closure observed afterwards and in the maintenance and reflex modulation of resting tone (2, 3).


Vagus Nerve Lower Esophageal Sphincter Gastrointestinal Motility Opiate Receptor Excitatory Response 
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© MTP Press Limited 1984

Authors and Affiliations

  • A. Jean
  • J. P. Miolan
  • C. Roman

There are no affiliations available

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