Disorganisation of the Interdigestive Small Bowel Motility by E. coli Endotoxin in the Rat
There is a growing awareness that enteropathogenic bacteria can mediate intestinal dysfunction not only via effects on secretion but also by affecting intestinal motility. Thus, in the rabbit ileal loop model, a number of bacteria and bacterial toxins — Vibrio cholerae cholera toxin, enteroinvasive E.coli heat-stable (ST) E.coli enterotoxin etc — are known to produce alterations in the myoelectric pattern (1–3).
KeywordsCholera Toxin Gastrointestinal Motility Myoelectric Activity Gastric Emptying Rate Small Bowel Length
Unable to display preview. Download preview PDF.
- 3.Mathias, J.R., Nogueira, J., Martin, J.L., Carlson,G.M. and Giannella, R.A. (1982). Am. J. Fhysiol., 242, G360 - G363Google Scholar
- 5.Ruckebusch, M. And Fioramonti, J. (1975). Electrical spiking activity and propulsion in small intestine in fed and fasted rats. Gastroenterology, 68, 1500–1508Google Scholar
- 6.Wilén, T., Gustaysson, S. and Jung, B. (1983). Evidence for a Propulsive Function of the Migrating Myoelectric Complex (MMC) in Rats. Eur. surg. Res., in pressGoogle Scholar
- 7.Rönnberg, B. and Wadström, T. (1983) Improved Method for Purification of Human Escherichia coli Heat-Stable Enterotoxin by Hydrophobic Interaction, Molecular -Sieve and High Performance Liquid Chromatography. Prep. Biochem., in pressGoogle Scholar
- 8.Gustaysson, S., Rönnberg, B., Sthle, E., Wilén, T. and Wadström, T. (1983). Disorganisation of the Small Bowel Transport Pattern by E.Coli Heat-Stable (ST) Enterotoxin in a Rat Model. Experimental Bacterial and Parasitic Infections, eds. Keusch and Wadström, pp 219–223Google Scholar
- 10.van Miert, A.S.J.P.A.M and van Duin, C.Th.M. (1980). Endotoxin-Induced Inhibition of Gastric Emptying Rate in the Rat. The Effect of Repeated Administration and the Influence of some Antipyretic Agents. Arch. int. Pharmacodyn., 246, 19–27.Google Scholar