Advertisement

Stimulating Effects of Cisapride on Antroduodenal Motility in the Conscious Dog

  • J. A. J. Schuurkes
  • L. M. A. Akkermans
  • J. M. Van Nueten

Summary

The effects of cisapride on gastroduodenal motility and gastric emptying were studied in conscious dogs, implanted with strain gauge force transducers or gastric cannulas. In the digestive state, cisapride (1.25 mg/kg p.o.) doubled contractile amplitude, reduced (20 %) contractile frequencies of antrum and duodenum, and improved antroduodenal coordination (25 → 60 %). The minimal effective dose was 0.31 mg/kg p.o. Cisapride was significantly more effective than metoclopramide on all parameters tested. Isopropamide (0.04 mg/kg i.v.) abolished the motor-stimulating effects of cisapride. Cisapride accelerated the emptying of a liquid (gastric cannula dogs) and semi-solid and solid (Tc-99m tin colloid labelled) test meal. Minimal effective dose was 0.16 mg/kg i.v. In the interdigestive state, cisapride (0.63 mg/kg i.v.) induced contractions on antrum and duodenum as strong as but not similar to phase III contractions. Cisapride appears to be a potent stimulator of digestive and interdigestive gastroduodenal motility. It improves gastric emptying of liquid, semi-solid and solid test meals.

Keywords

Gastric Emptying Test Meal Gastrointestinal Motility Minimal Effective Dose Duodenogastric Reflux 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Van Nueten, J.M., Van Daele, P.G.H., Reyntjens, A.J., Janssen, P.A.J. and Schuurkes, J.A.J. (1983). Gastrointestinal motility stimulating properties of cisapride, a non-antidopaminergic, non-cholinergic compound. This book, chapter, pp.Google Scholar
  2. 2.
    Schuurkes, J.A.J. and Van Nueten, J.M. (1983). Control of gastroduodenal coordination: dopaminergic and cholinergic pathways. Scand. J. Gastroenterol. (Suppl. 2nd Int. Symp. Duodenogastric Reflux, Brunnen, June 1983 )Google Scholar
  3. 3.
    Siegel, S. (1956). Nonparametric Statistics, pp. 75–83 ( McGraw Hill, New York )Google Scholar
  4. 4.
    Jacobs, F., Akkermans, L.M.A., Hong Yoe, O. and Wittebol, P. (1981). Effects of domperidone on gastric emptying of semi-solid and solid food. In: Towse, G. (ed). Progress with Domperidone, a Gastrokinetic and Anti-Emetic Agent. pp. 11–20. ( The Royal Society of Medicine, ICSS No. 36 )Google Scholar
  5. 5.
    Jacobs, F., Akkermans, L.M.A., Hong You, O., Hoekstra, A. and Wittebol, P. (1982). A radioisotope method to quantify the function of fundus, antrum, and their contractile activity in gastric emptying of a semi-solid and solid meal. In: Wienbeck, M. (ed). Motility of the Digestive Tract. pp. 233–240. ( Raven Press, N.Y. )Google Scholar
  6. 6.
    Reyntjens, A.J., Verlinden, M.H.J.J., Schuurkes, J.A.J., Van Nueten, J.M. and Janssen, P.A.J. (1983). New approach to gastrointestinal motor dysfunction: non-antidopaminergic, non-cholinergic selective stimulation with cisapride. Submitted for publication.Google Scholar

Copyright information

© MTP Press Limited 1984

Authors and Affiliations

  • J. A. J. Schuurkes
  • L. M. A. Akkermans
  • J. M. Van Nueten

There are no affiliations available

Personalised recommendations