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Dual Effect of Substance P on Canine Antral Muscle

  • E. A. Mayer
  • S. Khawaja
  • J. Elashoff
  • J. H. Walsh

Abstract

Substance P (SP) is widely distributed in neuronal structures of the mammalian gut. The peptide is known to have excitatory effects on various gastrointestinal tissues both in vivo and in vitro and this effect appears to be partially mediated by acetylcholine release from the myenteric plexus. In this study we sought (1) to describe the SP effect on the canine antral muscle in vitro and (2) to characterize its mechanism of action. Longitudinal (LAM) and circular (CAM) antral muscle strips from 30 mongrel dogs were studied using conventional organ bath techniques as previously described (Am. J. Physiol., 242: G141, 1982).

Keywords

Excitatory Effect Gastrointestinal Motility Myenteric Plexus Dual Effect Acetylcholine Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© MTP Press Limited 1984

Authors and Affiliations

  • E. A. Mayer
  • S. Khawaja
  • J. Elashoff
  • J. H. Walsh

There are no affiliations available

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