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Effect of Dopamine or Dopamine Blocker on the Antral Motility in Isolated Perfused Rat Stomach

  • W. Y. Chey
  • S. K. Odaibo
  • K. Y. Lee

Abstract

In isolated perfused rat stomach preparation, effects of dopamine; domperidone, a peripheral dopamine blocker; secretin; and cholecystokinin-octapeptide (CCK-OP) on the antral motility were studied. While the stomach was perfused with Krebs-Ringer (K-R) solution at a rate of 1.1 ml/min via celiac artery, motility was recorded through a open tip tube placed in the antrum which was connected to the Statham pressure transducer and Harvard peristaltic pump (0.03 ml/min). Gastric fluid was drained by a tube placed in the proximal duodenum. Peptides or drugs were infused through the celiac artery. Results: 1) Domperidone produced dose-dependent increases (r=0.68) in motility at doses of 0.08, 0.16, 0.32 and 0.64 μg, 2) Dopamine produced dose-dependent decreases in motility (r=0.76) at dose of 0.13, 0.25 and 0.5 μg which were reversed by domperidone, 0.32 pg, 3) Secretin inhibited the motility in a dose-dependent manner (r=0.49) at doses of 62.5, 125 and 250 pg which were also reversed by domperidone, 0.64 μg, 4) CCK-OP produced inhibition of motility at dose of 40 ng (p<0.025) which was also reversed by domperidone, 0.32 μg. In conclusion, local dopamine receptors in the rat stomach have an inhibitory effect on antral motility, while a peripheral dopamine blocker, domperidone, exerts a gastrotonic effect on spontaneous and inhibited antral motility by either secretin or CCK-OP. Thus, local dopamine receptors in the stomach appear to play a significant role on regulation of antral motility in physiological state.

Keywords

Significant Role Physiological State Press Limited Gastrointestinal Motility Gastric Fluid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© MTP Press Limited 1984

Authors and Affiliations

  • W. Y. Chey
  • S. K. Odaibo
  • K. Y. Lee

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